陆林 教授
研究领域: 病理性情感记忆及相关精神疾病干预的神经机制
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联系邮箱: [email protected]
个人简历
国家杰出青年基金获得者、“973 计划”首席科学家、国家自然科学基金委创新群体首席科学家
男，1966 年出生。现任北京大学教授、博士生导师、北京大学第六医院院长/北京大学精神卫生研究所长，北京大学中国药物依赖性研究所所长。担任美国神经免疫药理学会Councillor、中国药物依赖专业委员会主任委员、中国毒理学会常务理事、中国神经科学会精神病专业委员会常委和中国药理学会神经药理专业委员会委员；担任《中国药物依赖性杂志》主编、国际SCI 杂志Drug Alcohol Depen.副主编、Plos One 编辑及Int. J. Ment. Health Addict.和Am. J. Drug Alcohol Abuse 编委，以及Sciecne, Nat. Med., Nat. Neurosci., J. Neurosci.和Biol. Psych.等三十余种国际杂志审稿人。主要研究方向为精神疾病的神经生物学机制。在国际性SCI 期刊上发表学术论文100 余篇，包括Science, Nat. Neurosci., Trends in Neurosci., Am. J. Psych.，Biol. Psych. 和 J. Neurosci.等，其中有十余篇文章被SCI 期刊引用率超过100 次，总引用率超过4000 多次。主编（译）或参编论著15 部，其中英文论著2 部。
主要研究领域
1.抑郁症等情感障碍疾病的临床特征和药物作用机制
2.物质依赖相关疾病的分子生物学机制及非药理学干预模式
3.病理性情感记忆储存和消退的神经环路机制
代表性论文
1) Han Y, Luo Y, Sun J, Ding Z, Liu J, Yan W, Jian M, Xue Y, Shi J, Wang JS, Lu L*. AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation. Neuropsychopharmacology. 2015 Dec 9. [Epub ahead of print] (IF=7.048)
2) Xue YX, Zhu ZZ, Han HB, Liu JF, Meng SQ, Chen C, Yang JL, Wu P, Lu L*. Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory. Neuropsychopharmacology. 2015;40(10):2487. (IF=7.048)
3) Luo YX, Xue YX, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L*. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015;14(6):7675. (IF=11.47)
4) Liu JF, Yang C, Deng JH, Yan W, Wang HM, Luo YX, Shi HS, Meng SQ, Chai BS, Fang Q, Chai N, Xue YX, Sun J, Chen C, Wang XY, Wang JS*, Lu L*. Role of hippocampal β-adrenergic and glucocorticoid receptors in the novelty-induced enhancement of fear extinction. J Neurosci. 2015 May 27;35(21):8308-21. (IF=6.747)
5) He J, Sun HQ, Li SX, Zhang WH, Shi J, Ai SZ, Li Y, Li XJ, Tang XD*, Lu L*. Effect of conditioned stimulus exposure during slow wave sleep on fear memory extinction in humans. Sleep. 2015 Mar 1;38(3):423-31. (IF=5.062)
6) Zhang Y#, Xue Y#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J*. Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse. Biological Psychiatry. 2015, doi: 10.1016/j.biopsych.2015.07.007. (IF:10.26)
7) Sun Y, Zhao LY, Wang GB, Yue WH, He Y, Shu N, Lin QX, Wang F, Li JL, Chen N, Kosten TR, Feng JJ, Tan YL, Han HB, Lu L, Shi J*. ZNF804A variants confer risk for heroin addiction by modulating neurocognitive and neuroanatomical phenotypes. Addiction Biology. 2015, doi: 10.1111/adb.12233. (IF:5.36)
8) Sun Y#, Wang GB#, Lin QX#, Lu L, Shu N, Meng SQ, Wang J, Han HB, Yong H, Shi J*. Disrupted white matter structural connectivity in heroin abusers. Addiction Biology. 2015, doi: 10.1111/adb.12285. (IF:5.36)
9) Sun Y#, Hu D#, Liang J#, Bao YP, Meng SQ, Lu L, Shi J*. Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis. Schizophrenia Research. 2015, 162(1-3): 124-137. (IF:3.92)
10) Sun Y, Zhang Y, Wang F, Sun YK, Shi J*, Lu L*. From Genetic Studies to Precision Medicine in Alcohol Dependence. Behavioural Pharmacology. 2015, doi:10.1097/FBP.0000000000000202. (IF=2.15)
11) Liu J, Zhao L, Xue Y, Shi J, Suo L, Luo Y, Chai B, Yang C, Fang Q, Zhang Y, Bao Y, Pickens CL, Lu L*. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory. Biol Psychiatry. 2014;76(11):895-901. (IF=9.472)
12) Jian M, Luo YX, Xue YX, Han Y, Shi HS, Liu JF, Yan W, Wu P, Meng SQ, Deng JH, Shen HW, Shi J*, Lu L*. eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. J Neurosci. 2014 Jul 23;34(30):10010-21. (IF=6.747)
13) Xue YX, Xue LF, Liu JF, He J, Deng JH, Sun SC, Han HB, Luo YX, Xu LZ, Wu P and Lu L*. Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories. J Neurosci. 7 May 2014, 34(19):6647-6658. (IF=6.747)
14) Chai N, Liu JF, Xue YX, Yang C, Yan W, Wang HM, Luo YX, Shi HS, Wang JS, Bao YP, Meng SQ, Ding ZB, Wang XY*, Lu L*. Delayed Noradrenergic Activation in the Dorsal Hippocampus Promotes the Long-Term Persistence of Extinguished Fear. Neuropsychopharmacology. 2014 Jul;39(8):1933-45. (IF=7.833)
15) Suo L, Zhao L, Si J, Liu J, Zhu W, Chai B, Zhang Y, Feng J, Ding Z, Luo Y, Shi H, Shi J*, Lu L*. Predictable chronic mild stress in adolescence increases resilience in adulthood. Neuropsychopharmacology. 2013;38(8):1387-400. (IF=7.833)
16) Ren ZY, Liu MM, Xue YX, Ding ZB, Xue LF, Zhai SD, Lu L*. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013;38(5):778-90. (IF=7.833)
17) Zhu WL, Wang SJ, Liu MM, Shi HS, Zhang RX, Liu JF, Ding ZB, Lu L*. Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats. J Psychiatry Neurosci. 2013 Sep; 38(5):306-16. (IF=7.492)
科研项目