杨宝学 教授

研究领域: 肾脏与心血管药理学
电话:
联系邮箱: [email protected]

个人简历

男，1962 年出生。北京大学教授、博士生导师。中国药理学会理事，北京生理科学会理事，北京药理学会常务理事，中国药理学会麻醉药理学专业委员会副秘书长，中国药理学会心血管药理学专业委员会委员，中国药理学会生物化学药理学专业委员会委员，中国生理学会肾脏专业委员会委员， Front. Renal Epithelial Physiol.编委，《中华现代临床医学杂志》常务编委，《神经药理学报》编委，《基础医学与临床》编委，J. Am. Soc. Nephrol.等10 余个国际重要期刊的审稿人，国家科技奖励评审专家和自然科学基金评审专家等。主要从事药效学评价模型建立与应用、先导化合物发现与药效学评价、膜通道蛋白与心血管药理学、新型利尿药研发等研究。共发表SCI 收录论文90 余篇，申报专利4 项。

主要研究领域

1.药物筛选新方法、新策略

2.先导化合物发现与药效学评价

3.膜通道蛋白与心血管药理学

4.新型利尿药研发

代表性论文

（1）Wang W., F. Li, Y. Sun, L. Lei, H. Zhou, T. Lei, Y. Xia, A. S. Verkman, and B. Yang*. (2015) Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB J 29(4):1551-1563. [IF 5.043]

（2）Zhong D., H. Wang, M. Liu, X. Li, M. Huang, H. Zhou, S. Lin, Z. Lin, and B. Yang*. Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress. Sci Rep 5:16910. doi: 10.1038/srep16910. [IF 5.578]

（3）Sun Y., C. Lau, Y. Jia, Y. Li, W. Wang, J. Ran, F. Li, Y. Huang, H. Zhou* and B. Yang*.  Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway. Sci Rep (Accepted). [IF 5.578]

（4）Chen J., W. Cui, Q. Zhang, Y. Jia, Y. Sun, L. Weng, D. Luo, H. Zhou H, and B. Yang*. (2015) Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes. Am J Transl Res 7(9):1553-1563. [IF 3.402]

（5）Li Y., D. Zhong, L. Lei, Y. Jia, H. Zhou, and B. Yang*. (2015) Propofol prevents renal ischemia reperfusion injury via inhibiting the oxidative stress pathways. Cell Physiol Biochem. 37(1):14-26. [IF 2.875]

（6）Kang L., J. Mao, Y. Tao, B. Song, W. Ma, Y. Lu, L Zhao, J. Li, B. Yang*, and L. Li*. (2015) MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci 106(6):700-708. [IF 3.534]

（7）Ren H, Y. Wang, Y. Xing, J. Ran, M. Liu, T. Lei, H. Zhou, R. Li, J.M. Sands, and B. Yang*. (2014) Thienoquinolins exert diuresis by strongly inhibiting UT-A ureatransporters. Am J Physiol Renal Physiol. 307(12):F1363-F1372. [IF 3.3]

（8）Li M., W.I. Tou, H. Zhou, F. Li, H. Ren, C.Y. Chen*, and B. Yang*.  (2014) Developing hypothetical inhibition mechanism of novel urea transporter B inhibitor. Sci Rep 4:5775. doi: 10.1038/srep05775. [IF 5.078]

（9）Li C., H. Xue, Y. Lei, J. Zhu, B. Yang, and X. Gai. (2015) Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder. Pathol Res Pract. 210(12):799-803. [IF 1.562]

（10）Li F., T. Lei, J. Zhu, W. Wang, Y. Sun, J. Chen, Z. Dong, H. Zhou and B. Yang*. (2013) A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic. Kidney Int 83: 1076–1086. [IF7.916]

（11）Dong Z., J. Ran, H. Zhou, J. Chen, T. Lei, W. Wang, Y. Sun1, G. Lin, L. Bankir and B. Yang*. (2013) Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium. Plos One 30 Aug 2013: PONE-D-13-23855. [IF 3.73]

科研项目