王夔 院士

研究领域: 生物无机化学及无机药物
电话: +86-10-82801539
联系邮箱: [email protected]

个人简历

学术委员会名誉主任、中国科学院院士

男，1928 年出生，1949 年本科毕业于燕京大学化学系。现任北京大学医学部药学院教授，中国科学院院士及学部主席团成员。研究方向为与疾病相关的细胞无机化学。主要研究无机化合物生物效应的化学基础及其规律。目前研究包括：①无机化合物调节和控制细胞生命（如增殖、分化和凋亡）和功能的化学基础；②无机化合物作用于细胞，干预细胞信号转导的机理；③基于无机离子对病理过程的干预和调整研究新型无机药物。在大骨节病病理化学研究中，提出了异常细胞-异常基质-异常矿化的理论，把已有的三种大骨节病病因说统一起来；在胆红素研究中，阐述了色素型胆结石形成的自由基化学过程；在顺铂类抗癌药物与细胞的相互作用的研究中，找到了几种毒性低，抗癌活性强的铂络合物；在稀土和其它金属离子的生物效应的化学基础研究中，阐明了稀土吸收和跨血脑屏障的机制，阐明了稀土促进细胞增殖和凋亡的信号转导机制，阐明了稀土毒性的分子机制。自70 年代以来，率先在国内倡导和开展了细胞生物无机化学研究，在细胞层次上研究无机离子生物效应的机理，阐明它们与病理和毒理过程的关系，提出了细胞作为多靶反应系统应答无机物，无机物的跨膜运输是具有手性选择性的多途径、多步骤的复杂化学过程，总结了无机离子生物效应的“相似作用规律”。近年来，提出了“预防药学”的新概念，开辟了药物研究的新领域。曾获教委及教育部科技进步一等奖、二等奖及三等奖各一项以及中科院科学进步二等奖和三等奖各一项(分课题)，获何梁何利科学与进步奖。

主要研究领域

细胞无机化学：病理、药理和毒理过程的无机化学基础 

无机药物化学：以金属为基础的预防和治疗药物

代表性论文

1. Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration. Dong S, Zhao YB, Liu HX*, Yang XD, Wang K*. Bio. Metals. 2009, 22: 917-926.
2. Q. Yang, J. Hu, X. Yang, K. Wang, Mastoparan/Mastoparan X Altered Binding Behaviorof La3+ to Calmodulin in Ternary Complexes, J. Inorg. Biochem., 2008,102(2):278-284.
3. Wang Q, Yang XD, Zhang BX, Yang XW, Wang K. The anxiolytic effect of cinnabar involves changes of serotonin levels. Eur. J. Pharmacol., 2007, 565: 132-137.
4. Yu, S., Hu, J., Yang, X., Wang, K., Qian, ZM, La3+-Induced Extracellular Signal-Regulated Kinase (ERK) Signaling via a Metal-Sensing Mechanism, Biochemistry, 2006, 45, 11217-11225.
5. J. Huang, T. Zhang, S. Xu, R. Li, K.i Wang, J. Zhang, Y.Xie. Effects of lanthanum on composition, crystal size and lattice structure of femur bone mineral. Calcif Tissue Int, 2006, 78, 241-247.
6. H.Ding, C.Wang,T.Zhang, K.Wang, Fibronectin Enhances In Vitro Vascular Calcification by Promoting Osteoblastic Differentiation of Vascular Smooth Muscle Cells. J Cell Biochem 2006, 99:1343-1352.
7. Zhang, Y., Yang, ,X., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium (III, IV, V)-Dipicolinate Complexes, J.Inorg.Biochem., 2006, 100: 80-97.
8. H. Liu, L. Yuan, S. Xu, K. Wang, T. Zhang. Cholestane-3,5,6-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow  stromal cells. J Cell Biochem, 2005, 94, 198-208.
9. Hu, J.; Yang, X.; Wang, K., La3+ stimulate the activity of calcineurin in two different ways. J Biol Inorg Chem, 2005, 10:704-711.
10. S. Yu, L. Yuan, X. Yang, K. Wang, Z. Qian, La3+-Promoted Proliferation Could Be Interconnected with Apoptosis in NIH 3T3 Cells, J. Cell. Biochem. 2005, 94, 508-519.
11. X. Yang, X. Yang,, K. Wang, D.C. Crans, The Permeability and Cytotoxicity of Insulin-mimetic Vanadium Compounds, Pharm. Res., 2004, 21/6, 1026-1033.
12. Du X., Wang K., Ke Y., Yuan L., Li R.-C., Chang Y.-Z., Ho K. P., Qian Z. M., Apotransferrin is internalized and distributed in the same way as holotransferrin in K562 cells, J.Cell Physiol.,2004, 201, 45–54.
13. J. Hu, X. Jia, Q. Li, X. Yang and K. Wang, La3+ Binds to Ca2+ Sites of Calmodulin but Results in Altered Conformation and Kinetic Properties as Binding of  Calmodulin to Mastoparan, Biochemistry, 2004, 43, 2688-2698.
14. Hu, J., Yang, X. and Wang, K., The Different Fluorescent Response of Quin 2 to the Binding of Ca2+ and La3+ and its Application, Chinese Chem. Lett., 2004, 15/10, 1197-1200.
15. X. Yang, K. Wang, J. Lu, D.C. Crans, The biopotency of anti-diabetes vanadium compounds depends on cross membrane transport and interaction with cell membrane An in vitro study with human erythrocytes as model system, Coordination Chemical Review, 2003, 237: 103-111.
16. H. Liu, L. Yuan, X. Yang, K. Wang, La3+, Gd3+ and Yb3+ induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level. Chemico-Biological Interactions, 2003,146, 27-37.
17. Wang, HP., Feng, XJ., Zhang, TL., Xu, SJ.Wang, K., Effects of LDL, cholesterol and their oxidized forms on the precipitation kinetics of calcium phosphates, Clin Chem, 2003, 49(12): 2027-2036.
18. Du X, Zhang T, Yuan L, Zhao Y, Li R, Wang K, Yan S, Zhang L., Sun H, Qian Z, Complexation of Ytterbium to human transferrin and its uptake by K562 cells, Eur. J. Biochem. 2002, 269: 6082-6090.

科研项目