张强 教授

研究领域: 分子药剂学
电话: +86-10-82802791
联系邮箱: [email protected]

个人简历

 “973 计划”首席科学家、教育部创新团队负责人

男，1958 年出生。北京大学药学院教授、博士生导师。中国药学会常务理事、中国药学会药剂专业委员会名誉主任、中国药学会纳米药物专业委员会副主任、国家药典会委员制剂专业委员会副主任、《中国药学杂志》和《药学学报》副主编、J. Control. Release、Nanomed.:NBM 等国际杂志编委。曾任世界控释协会（CRS）中国分会首任主席、中国药学会药剂专业委员会主任委员、北京大学药学院副院长。长期从事创新药物制剂的研究与开发，在国内首批开展蛋白多肽药物给药系统、新型纳米给药系统、新型受体介导主动靶向给药系统和分子药剂学研究；主编或参编专著与教材15 部；在Adv. Funct. Mater., J. Control. Release, Biomaterials, Nanomedicine:BNM, Nanoscale等本领域权威学术杂志上发表论文300 多篇，被引用6000 多次；完成创新制剂研究30 余项，申请国内外发明专利40 多项；开发上市多个新型释药系统；获教育部自然科学一等奖、中国药学会科学技术一等奖、吴阶平-保罗•杨森医药奖一等奖、中国药学发展奖、全国优秀科技工作者和国务院特殊津贴。

主要研究领域

 1.新型靶向给药系统研究

2.纳米技术增加药物口服吸收的分子机理

代表性论文

1. Dong Mei, Zhiqiang Lin, Jijun Fu, Bing He, Wei Gao, Ling Ma, Wenbing Dai, Hua Zhang,Xueqing Wang, Jiancheng Wang, Xuan Zhang, Wanliang Lu, Demin Zhou, Qiang Zhang The use of a-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to a7 nAChR-overexpressing breast. Biomaterials, 2015, 42: 52-65.(8.557)

2. Jijun Fu1, Dan Wang1, Dong Mei, Haoran Zhang, Zhaoyang Wang, Bing He, Wenbing Dai, Hua Zhang,Xueqing Wang, Qiang Zhang* Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer. Journal of Controlled Release, 2015, 204: 11–19.(7.705)

3. Hongxiang Hu, Zhiqiang Lin, Bing He,Wenbing Dai,Xueqing Wang,Jiancheng Wang , Xuan Zhang，Hua Zhang*, Qiang Zhang** A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel. Journal of Controlled Release, , 2015, 220: 189-200.(7.705)

4. Zhiqiang Lin, Dong Mei, Meiwan Chen,Yitao Wang,Xianhui Chen，Zhaoyang Wang,Bing He,Hua Zhang,Xueqing Wang,Wenbing Dai*，Yuxin Yin*，and Qiang Zhang* A comparative study of thermo-sensitive hydrogels with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal. Nanoscale, 2015, 7(36): 14838–14847.(7.394)

5. Hua Zhang, Hongxiang Hu, Haoran Zhang, Wenbing Dai, Xinglin Wang,Xueqing Wang* and Qiang Zhang* Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis. Nanoscale, 2015, 7(24): 10790–10800.(7.394)

6. Wenwen Du, Yuchen Fan, Bing He, Nan Zheng, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang,and Qiang Zhang* Bionano Interactions of MCF‑7 Breast Tumor Cells with a Transferrin Receptor Targeted Nanoparticle. Molecular Pharmaceutics, 2015, 12(5): 1467−1476.(4.384)

7. Zhaoming Guo, Bing He, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Dual targeting for metastatic breast cancer and tumor neovasculature by EphA2-mediated nanocarriers. International Journal of Pharmaceutics, 2015, 493(1-2): 380–389.(3.65)

8. Suna He, Zheng Cui, Xueqing Wang, Hua Zhang, Wenbing Dai, Qiang Zhang* Cremophor-free intravenous self-microemulsions for teniposide:Safety, antitumor activity in vitro and in vivo. International Journal of Pharmaceutics, 2015, 495(1): 144–153.(3.65)

9. Wenbing Dai1, Yulan Guo1, Hua Zhang, Xueqing Wang, Qiang Zhang* Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A. International Journal of Pharmaceutics, 2015, 478 (2): 718–725.(3.65)

10. Wenbing Dai1, Yuchen Fan1, Hua Zhang, Xueqing Wang, Qiang Zhang*, and Xinglin Wang A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma. Drug Delivery, 2015, 22(1): 10–20.(2.558)

11. Defu Cai, Wei Gao, Bing He, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy. Biomaterials, 2014, 35(7): 2283-2294. (8.312)

12. Wenbing Dai1, Fang Yang1, Ling Ma, Yuchen Fan, Bing He, Qihua He, Xueqing Wang, Hua Zhang, Qiang Zhang* Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer. Biomaterials, 2014, 35(20):5347-5358. (8.312)

13. Chao Qin, Bing He, Wenbing Dai, Zhiqiang Lin, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Guangji Wang*, Lifang Yin*, Qiang Zhang* The impact of a chlorotoxin-modified liposome system on receptor MMP-2 and the receptor-associated protein ClC-3. Biomaterials, 2014, 35(22): 5908-5920. (8.312)

14. Zhaoming Guo, Bing He, Hongwei Jin, Haoran Zhang, Wenbing Dai, Liangren Zhang, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin αvβ3 clustering. Biomaterials, 2014, 35(23): 6106-6117. (8.312)

15. Xueqing Wang, Suxin Li, Yujie Shi, Xingxing Chuan, Ji Li, Ting Zhong, Hua Zhang, Wenbing Dai, Bing He, Qiang Zhang* The development of site-specific drug delivery nanocarriers based on receptor mediation. J. Control. Release, 2014, 193: 139-153. (7.261)

16. Zhiqiang Lin , Wei Gao, Hongxiang Hu, Kun Ma, Bing He, Wenbing Dai, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. J. Control. Release, 2014, 174: 161–170. (7.261)

17. Hua Zhang, Xueqing Wang, Wenbing Dai, Richard A. Gemeinhart, Qiang Zhang*, Tonglei Li* Pharmacokinetics and treatment efficacy of camptothecin nanocrystals on lung metastasis. Mol. Pharmaceutics, 2014, 11(1):226-233. (4.787)

18. Wei Gao, Zhiqiang Lin, Meiwan Chen, Xiucong Yang, Zheng Cui, Xiaofei Zhang, Lan Yuan, Qiang Zhang* The co-delivery of a low-dose P-glycoprotein inhibitor with doxorubicin sterically stabilized liposomes against breast cancer with low P-glycoprotein expression. Int. J. Nanomedicine, 2014, 9: 3425-3437. (4.195)

19. Jingkai Lu1, Xingxing Chuan1, Hua Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang*, Qiang Zhang* Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: preparation and comparison with other paclitaxel systems in vitro and in vivo. Int. J. Pharm., 2014, 471(1-2): 525-535. (3.785)

20. Hua Zhang, Yuan Meng, Xueqing Wang, Wenbing Dai, Xinglin Wang, Qiang Zhang* Pharmaceutical and pharmacpkinetic characteristics of different types of fenofibrate nanocrystals prepared by different bottom-up approaches. Drug Delivery, 2014, 21(8): 588-594. (2.202)

21. Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang,* and Qiang Zhang Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)−Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Mol. Pharmaceutics, 2014, 11(10), 3656−3670. (4.787)

22. Bo Zhao, Xueqing Wang*, Xiaoyou Wang, Hua Zhang, Wenbing Dai, Jun Wang, Zhenlin Zhong, Hounan Wu, Qiang Zhang*. Nanotoxicity comparison of four amphiphilic polymeric micelles with similar hydrophilic or hydrophobic structure. Part. Fibre Toxicol. 2013 10:47, Doi: 10.1186/1743-8977-10-47.(9.178)

23. Bing He, Ping Lin, Zengrong Jia, Wenwen Du, Wei Qu, Lan Yuan, Wenbing Dai, Hua Zhang,Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells. Biomaterials ,2013, 34(25): 6082-6098.(7.604)

24. Bing He, Zengrong Jia, Wenwen Du, Chao Yu, Yuchen Fan, Wenbing Dai, Lan Yuan,Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* The transport pathways of polymer nanoparticles in MDCK epithelial cells. Biomaterials, 2013, 34(17): 4309-4326. (7.604)

25. Yuchen Fan, Wenwen Du, Bing He, Fengying Fu, Lan Yuan, Hounan Wu, Wenbing Dai, Hua Zhang , Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* The reduction of tumor interstitial fluid pressure by liposomal imatinib and its effect on combination therapy with liposomal doxorubicin. Biomaterials, 2013, 34(9): 2277-2288. (7.604)

26. Zhaohui Wang, Yang Yu, Wenbing Dai, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth. Biomaterials, 2013, 34(3): 756-764. (7.604)

27. Wenwen Du, Yuchen Fan, Nan Zheng, Bing He, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery. Biomaterials, 2013, 34(3): 794-806. (7.604)

28. Chao Yu, Bing He, Menghua Xiong, Hua Zhang, Lan Yuan, Ling Ma, Wenbing Dai, Jun Wang, Xinglin Wang, Xueqing Wang*, Qiang Zhang*. The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cells. Biomaterials, 2013,34(26): 6284-6298. (7.604)

29. Yuan-yuan Jiao, Xue-qing Wang, Wan-liang Lu, Zhen-jun Yang, Qiang Zhang* A novel approach to improve the pharmacokinetic properties of 8-chloro-adenosine by the dual combination of lipophilic derivatisation and liposome formulation. European Journal of Pharmaceutical Sciences 2013, 48(1-2): 249-258.(2.987)

30. Zhaohui Wang, Yang Yu, Wenbing Dai, Jingkai Lu, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer. Biomaterials, 2012, 33(33): 8451-8460.(7.404)

31. Yang Zhang, Hua Zhang , Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. The eradication of breast cancer and cancer stem cells using octreotide modifiedpaclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials. 2012, 33(2): 679-691.(7.404)

32. Wenbing Dai, Tingyuan Yang, Yiguang Wang, Xun Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang* Peptide PHSCNK as an integrin α5β1 antagonist targets stealth liposomes to integrin- overexpressing melanoma. Nanomedicine NBM. 2012，8(7): 1152-1161 (6.692)

33. Tingyuan Yang1, Yiguang Wang1, Zaiquan Li, Wenbing Dai, Jie Yin, Liang Liang, Xue Ying, Shufeng Zhou, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature. Nanomedicine: Nanotechnology, Biology, and Medicine. 2012, 8(1): 81–92. (6.692)

34. Liang Liang, Songwen Lin, Wenbing Dai, JingKai Lu, Tingyuan Yang, Yu Xiang, Yang Zhang, Runtao Li*, Qiang Zhang* Novel cathepsin B-sensitive paclitaxel conjugate: higher water solubility, better efficacy and lower toxicity. Journal of Controlled Release. 2012，160(3): 618-629. (6.499)

35. Shanshan Zhao, Wenbing Dai, Bing He, Jiancheng Wang, Zhonggui He, Xuan Zhang*, Qiang Zhang*. Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms. J. Control. Release. 2012, 158(3):413-23. (6.499)

36. Nan Zheng, Wenbing Dai, Wenwen Du, Haoran Zhang, Liandi Lei, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Jinming Gao, Qiang Zhang*. A Novel Lanreotide-Encoded Micelle System Targets Paclitaxel to the Tumors with Overexpression of Somatostatin Receptors. Mol. Pharmaceut., 2012, 9(5): 1175-1188.(4.782)

37. Zhaohui Wang, Yang Yu, Hua Zhang, Haoran Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, and Qiang Zhang* LyP-1 Modification To Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics. Molecular Pharmaceutics  . 2012，9(9): 2646-2657.(4.782)

38. Xue Qing Wang, Qiang Zhang* pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2012, 82(2): 219-229 (4.269)

39. Wenbing Dai, Wu Jin, Junlin Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, You Wan, Qiang Zhang* Spatiotemporally Controlled Co-delivery of Anti- vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes. Pharm Res. 2012，29(10): 2902-2911. (4.093)

40. Wei Qu, Yong Li*, Lars Hovgaard,Song Li,Wenbin Dai, Jiancheng Wang, Xuan Zhang, Qiang Zhang* A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1. Int. J. Nanomedicine 2012, 7: 4983–4994.(3.130)

41. Yu Xiang, Qian Wu, Liang Liang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Xiaoping Pu, Qiang Zhang. Chlorotoxin-modified stealth liposomes encapsulating levodopa for the targeting delivery against Parkinson's disease in the MPTP-induced mice model. J Drug Target. 2012，20(1): 67-75.(2.696)

42. Yu Xiang, Liang Liang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes. J. Control. Release. 2011, 152(3): 402-410. (7.164)

43. Yiguang Wang1, Tingyuan Yang1, Xun Wang, Wenbing Dai, Jiancheng Wang, Xuan Zhang, Zaiquan Li, Qiang Zhang*. Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system. J. Control. Release. 2011, 149 (3):299-306.(7.164)

44. Yuan Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Octreotide-modified polymeric micelles as potential carriers for targeted docetaxel delivery to somatostatin receptor overexpressing tumor cells. Pharm. Res. 2011, 28(5):1167-1178. (4.456)

45. Zengrong Jia, Ping Lin, Yu Xiang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate. European J. Pharma. Biopharm. 2011, 79(1): 126-134.(4.304)

46. Xueqing Wang, Jieming Fan, Yaou Liu, Bo Zhao, Zengrong Jia, Qiang Zhang*. Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat. Int. J. Pharm. 2011,419: 339-346. (3.607)

47. Jie Yin, Zaiquan Li, Tingyuan Yang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Cyclic RGDyK conjugation facilitates intracellular drug delivery of polymeric micelles to integrin-overexpressing tumor cells and neovasculature.J. Drug Target. 2011, 19(1):25-36. (3.466)

48. JinYang Zhang, Bing He, Wei Qu, Zheng Cui, Yibo Wang, Hua Zhang, Jian-Cheng Wang, and Qiang Zhang*. Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo. J. Microencapsul., 2011, 28(6): 528-536. (1.515)

49. Chuanyun Dai, Ya Fu, Biao Li, Yiguang Wang, Xuan Zhang, Jiancheng Wang, Qiang Zhang*. Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity of PEGylated tumor necrosis factor-alpha (TNF-α) against murine fibrosarcoma. Sci. China Life Sci. 2011, 54(2):128-138.(1.345)

科研项目