张亮仁 教授

研究领域: 药物化学与化学生物学
电话: +86-10-82802567
联系邮箱: [email protected]

个人简历

男，1963 年出生。北京大学教授、博士生导师、北京大学药物化学系主任。兼任中国药学会药物化学专业委员会委员，Heterocycles、Drug Discov. Ther.、Molecules、《药学学报》、《中国药物化学杂志》、《中国药学（英文版）》、《中国药学杂志》等期刊的编委或顾问编委。主要从事核苷、核苷酸及寡核苷酸药物的设计合成、构效关系研究，以及以结构为基础的药物设计与合成。先后主持包括国家自然科学基金、教育部博士点基金、新药创制重大专项等在内的多项科研项目。在国内外学术杂志发表研究论文170 余篇，曾获2002 年教育部自然科学奖二等奖(第2 完成人)、 2004 年国家自然科学二等奖(第2 完成人)。

主要研究领域

1.核苷、核苷酸及寡核苷酸药物的设计与合成

2.以结构为基础的药物设计与合成以及构效关系研究 

3.有机小分子对细胞信号传导系统的调控研究

代表性论文

1. J Xia, EL Tilahun, EH Kebede, TE Reid, LR Zhang*, XS Wang*, Comparative Modeling and Benchmarking Data Sets for Human Histone Deacetylases and Sirtuin Families. J. Chem. Inf. Model., 2015, 55(2), 374-388. (IF：3.738)

2. F Pei, HW Jin, X Zhou, J Xia, LD Sun, ZM Liu, LR Zhang*, Enrichment Assessment of Multiple Virtual Screening Strategies for Toll-Like Receptor 8 Agonists Based on a Maximal Unbiased Benchmarking Data Set. Chem. Biol. Drug. Design, 2015, 86(5), 185-198. (IF：2.485)

3. LX Zeng, MX Guan, HW Jin, ZM Liu* and LR Zhang*, Integrating Pharmacophore into Membrane Molecular Dynamics Simulations to Improve Homology Modeling of G Protein-coupled Receptors with Ligand Selectivity: A2A Adenosine Receptor as an Example. Chem. Biol. Drug. Design, 2015, 86(6), 1438-1450. (IF：2.485)

4. S Zhang, XW Xue, LR Zhang*, LH Zhang and ZM Liu*, Comparative Analysis of Pharmacophore Features and Quantitative Structure–Activity Relationships for CD38 Covalent and Non-covalent Inhibitors. Chem. Biol. Drug. Design, 2015, 86(6), 1411-1424. (IF：2.485)

5. Q Sun, B Xu, Y Niu*, FR Xu, L Liang, C Wang, JP Yu, G Yan, W Wang, HW Jin* and P Xu*. Synthesis, bioactivity, docking and molecular dynamic studies of furan-based peptidic molecules as 20S proteasome inhibitors. ChemMedChem, 2015, 10(3), 498-510. (IF：2.968)

6. R Yang, SY Yan, XJ Zhu, CY Li, ZM Liu*, JW Xiong*. Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish. Exp. Hematol., 2015, 43(4), 331-341. (IF: 2.475)

7. LR Zhang, JB Yue, LH Zhang. Cyclic Adenosine 5 '-Diphosphoribose (cADPR) Mimics Used as Molecular Probes in Cell Signaling. Chem. Records, 2015, 15(2), 511-523. (IF：5.492)

8. JS Tang, BX Xie, XL Bian, Y Xue, NN Wei, JH Zhou, YC Hao, G Li, LR Zhang*,  Ke-wei Wang*. Identification and in vitro pharmacological characterization of a novel and selective alpha 7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Acta Pharmacol. Sin., 2015, 36, 800-812. (IF: 2.825)

9. 曾凌晓，李欣然，金宏威，刘振明*，张亮仁*，基于结构和药效团特征的人类腺苷受体拮抗剂选择性比较，物理化学学报，2015, 31, 1584-1596. (IF: 0.852)

10. WJ Wei, YY Lu, BX Hao, KH Zhang, Q Wang, A Miller, LR Zhang, Lihe Zhang, JB Yue*, CD38 is required for neural differetiation of mouse embryonic stem cells by modulating reactive oxygen species (ROS). Stem Cells, 2015, 33, 1664-2673. (IF: 6.523)

11. J Xia, LR Zhang*, XS Wang*, Benchmarking Methods and Data Sets for Ligand Enrichment Assessment in Virtual Screening. Methods, 2015, 71, 146-157. (IF: 3.645)

12. LD Sun, HW Jin, XY Zhao, ZM Liu, YF Guan, ZJ Yang, LR Zhang*, LH Zhang. Search for unfolding and conformational variations of thrombin-binding DNA aptamer: synthesis, circular Dichroism and molecular dynamics simulation. ChemMedChem, 2014, 9, 993-1001. (IF: 3.046)

13. J Xia, HW Jin, ZM Liu, LR Zhang*, XS Wang*. A versatile protocol to build GPCR-specific Benchmarking Set (GBS) for Ligand Based Virtual Screening. J. Chem. Inf. Model., 2014, 54, 1433-1450. (IF: 3.738)

14. SJ Wang, WJ Zhu, X Wang, JG Li, KH Zhang, LR Zhang*, YJ Zhao, HC Lee, LH Zhang. Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase. Molecules, 2014, 19, 15754-15767. (IF: 1.988)

15. WL Huang, T Zuo, HW Jin, ZM Liu, ZJ Yang, XH Yu, LR Zhang*, LH Zhang, Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Mol. Div., 2013, 17, 221-243. (IF: 2.861)

16. LD Sun, F Tian, BS Feng, ZM Liu, LR Zhang *, JF Pei*, Computational Identification of a New Binding Site in Influenza Virus Hemagglutinin for Membrane Fusion Inhibitors. Chem. Biol. Drug Des., 2013, 82, 267-274. (IF: 2.469)

17. WL Huang, T Zuo, HW Jin, ZM Liu, ZJ Yang, XH Yu, LR Zhang*, LH Zhang, Indolizine Derivatives as HIV-1 VIF-ElonginC Interaction Inhibitors. Chem. Biol. Drug Des., 2013, 81, 730-741. (IF: 2.469)

18. YK Duan, HW Jin, H Yu, ZL Wang, LR Zhang*, JX Huo, Computational investigation of interactions between Cdc37 and celastrol. Mol. Simul., 2013, 39, 270-278. (IF: 1.056)

19. ZY Wang, S Li, LD Sun, JL Fan, Liu, ZM*. Comparative Analyses of Lipoprotein Lipase, Hepatic Lipase, and Endothelial Lipase, and Their Binding Properties with Known Inhibitors. PLoS ONE, 2013, 8: e72146. (IF: 3.73)

20. Z Liu, RM Graeff, HW Jin, LR Zhang, LH Zhang*, Studies on CD38 Inhibitors and Their Application to cADPR-Mediated Ca2+ Signaling. Messenger, 2013, 2, 1-14.

21. H Yu, HW Jin, LD Sun, LR Zhang, G Sun, ZL Wang*, YC Yu, Toll-like receptor 7 agonists: chemical feature based pharmacophore identification and molecular docking studies. PLoS ONE, 2013, 8, e56514. (IF: 3.73)

22. ZX Zhao, SY Gao, JC Wang*, CJ Chen, EY Zhao, WJ Hou, Q Feng, LY Gao, XY Liu, LR Zhang*, Qiang Zhang. Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery. Biomaterials, 2012, 33, 6793-6807. (IF: 7.404)

23. PL Yu, ZH Zhang, BX Hao, YJ Zhao, LH Zhang, HC Lee, LR Zhang*, JB Yue*. A Novel Fluorescent Cell Membrane Permeable Caged cyclic ADP-Ribose Analogue. J. Biol. Chem., 2012, 287, 24774-24783. (IF: 4.773)

24. Y Zhou, PL Yu, HW Jin, ZJ Yang, JB Yue, LR Zhang* and LH Zhang. Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications. Molecules, 2012, 17, 4343-4356. (IF: 2.386)

25. Y Zhou, KY Ting, CMC Lam, AKY Kwong, J Xia, HW Jin, ZM Liu, LR Zhang*, HC Lee, LH Zhang, Design, Synthesis and Biological Evaluation of Noncovalent Inhibitors of Human CD38 NADase. ChemMedChem, 2012, 7, 223-228. (IF: 3.306)

26. PL Yu, Q Wang, LH Zhang, HC Lee, LR Zhang, JB Yue*, A Cell Permeable NPE Caged ADP-Ribose for Studying TRPM2. PLoS ONE, 2012, 7, e51028. (IF: 3.730)

27. 乔康, 曾凌晓, 金宏威*, 刘振明, 张亮仁*, 人类腺苷受体A3亚型拮抗剂的构效关系分析, 物理化学学报, 2012, 28, 1509-1519. (IF: 0.869)

28. ZL Wang, LD Sun, HY, YH Zhang, WZ Gong, HW Jin, LR Zhang* and HP Liang*, Binding mode prediction of evodiamine within vanilloid receptor TRPV1. Int. J. Mol. Sci., 2012, 13, 8958-8969. (IF: 2.464)

29. T Zuo, DL Liu, W Lv, XD Wang, JW Wang, MY Lv, WL Huang, JX Wu, HH Zhang, HW Jin, LR Zhang, Wei Kong, and Xianghui Yu*, Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting of the Interaction between Vif and ElonginC. J. Virol., 2012, 8, 5497-5507. (IF: 5.076)

30. AKY Kwong, Z Chen, HM Zhang, FP Leung, CMC Lam, KY Ting, LR Zhang, Q Hao, LH Zhang*, HC Lee*. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry, 2012, 51, 555-564. (IF: 3.377)

31. 陈哲, AKY Kwong, 杨振军，张亮仁*，HC Lee, 张礼和，烟酰胺腺嘌呤二核苷酸（NAD）类CD38抑制剂的合成及活性评价. 高等学校化学学报，2012, 33, 1226-1232. (IF: 0.856)

32. Q Hu, AH Nie, K Welsh, FRP Criso´stomo, XJ Zhu, ZX Li, J An, JC Reed, LR Zhang* and ZW Huang, Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine. Exp. Biol. Med., 2011, 236, 247-251. (IF: 2.954)

33. YH Ma, Bo Xu, Y Fang, ZJ Yang, JR Cui, LR Zhang* and LH Zhang. Synthesis and SAR study of novel peptide aldehydes as inhibitors of 20S proteasome. Molecules, 2011, 16, 7551-7564. (IF: 1.988)

34. Z Chen, AKY Kwong, ZJ Yang, LR Zhang*, HC Lee, and LH Zhang. Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 NADase. Heterocycles, 2011, 83, 2837-2850. (IF: 1.093)

35. ZL Wang, SS Zhang, HW Jin, W Wang, JX Huo, LS Zhou, YF Wang, FQ Feng*, LR Zhang*. Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation. Eur. J. Med. Chem., 2011, 46, 3428-3433. (IF: 3.346)

36. YH  Ma, LL Qu, ZM Liu, LR Zhang*, ZJ Yang, LH Zhang, Synthesis of Salinosporamide A and Its Analogs as 20S Proteasome Inhibitors and SAR Summarization.  Curr. Top. Med. Chem., 2011, 11, 2906-2922. (IF: 4.174)

37. M Dong, YQ Si, SY Sun, XP Pu, ZJ Yang, LR Zhang, LH Zhang, FP Leung, CMC Lam, AKY Kwong, JB Yue, YY Zhou, IA Kriksunov, Q Hao, and HC Lee, Design, synthesis and biological characterization of novel inhibitors of CD38. Org. Biomol. Chem., 2011, 9, 3246-3257. (IF: 3.696) 

38. 樊迪，刘振明*，金宏威，张亮仁*, 基于结合位点的辅酶A结合蛋白家族的分类.，物理化学学报，2011，11，1223-1231. (IF: 0.780)

科研项目