杨振军 教授
研究领域: 核酸化学及核酸药物
电话: +86-10-82802503
联系邮箱: [email protected]
个人简历
男，1964 年出生。北京大学教授，博士生导师，药物化学系副主任。中国化学会化学生物学专业委员会委员，中国化学会化学教育专业委员会委员，江西师范大学功能有机小分子教育部重点实验室学术委员会委员，江西科技师范大学江西省有机功能分子重点实验室学术委员会委员，陕西师范大学药用植物资源与天然药物化学教育部重点实验室学术委员会委员；曾任国家自然科学基金委员会化学学部化学生物学流动项目主任。长期从事核酸相关的基础和应用研究，近5 年来以责任作者共发表研究论文34 篇，申请和授权专利15 项，其中国际PCT 专利申请2 项。曾获全国百篇优秀博士学位论文(2000)， 获教育部自然科学一等奖一项(第三完成人，1999)、二等奖两项(第三完成人，2002；第一完成人，2009)，国家自然科学二等奖一项(第五完成人，2004)。
主要研究领域
1.核苷类抗病毒药物研究
2.修饰的反义寡核苷酸和siRNA药物研究
代表性论文
1. DL Pan, J Sun, HW Jin, YT Li, LY Li, Y Wu, LH Zhang, ZJ Yang*, Supramolecular assemblies of novel aminonucleoside phospholipids and their bonding to nucleic acids, Chem. Commun., 2015, 51, 469-472.(SCI IF 6.834)
2. Y Huang, M Tian, G Sheng, YC Zhang, Z Chen, Y Ma, Y Chen, YH Peng, YL Zhao*, YL Wang, LH Zhang, ZJ Yang*, D-isonucleoside (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago 2-PAZ domain and enhances in vitro potency of siRNA, Org. Biomol. Chem., 2015, 13, 10825-10833. (SCI IF 3.562)
3. MJ Gu, KF Li, LX Zhang, H Wang, LS Liu, ZZ Zheng, ZJ Yang*, TY Fan*, A novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging, Inter. J. Nanomed., 2015, 10, 5187-5204. (SCI IF 4.383)
4. JF Zhu, ZW Li, ZJ Yang*, JL He*, Studies on the preferred uracil-adenine base pair at the cleavage site of 10-23 DNAzyme by functional group modifications on adenine, Bioorg. Med. Chem., 2015, 23, 4256–4263. (SCI IF 2.793)
5. 王雨斯, 马元, 刘欣洁, 张礼和, 杨振军*, 茎环引物PCR用于定量检测异核苷修饰siRNA的可行性研究, 中国科学-化学, 2015, 45(7), 710-718.
6. 蒙卓明，杨先桃，郭颖，关注*，张礼和，杨振军, 6-取代氨基-L-D4G/ddG-5’-单磷酸酯的合成与抗HIV活性研究, 中国药化杂志, 2015, 25(2), 93-99.
7. J Sun, JC Wang, ZJ Yang*, The supramolecular assembly models of siRNA deliverysystem [Review], Chin. J. Chem., 2015, 33, 79-89. (SCI IF 1.578)
8. 那路新, 刘欣, 蒙卓明, 关注, 张礼和, 杨振军*, 生物素光亲和分子的设计合成及其对2’-O-炔丙基鸟苷的标记, 药学学报, 2015, 50(1), 59-63.
9. LY Li, JJ Hou, XJ Liu, YJ Guo, Y Wu*, LH Zhang,ZJ Yang*, Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas, Biomaterials, 2014, 35, 3840-3850. (SCI IF 8.312)
10. BB Cai, XT Yang, LD Sun, XM Fan, LY Li, HW Jin, Y Wu, Z Guan, LR Zhang, LH Zhang, ZJ Yang*, Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions, Org. Biomol. Chem., 2014, 12, 8866-8876.(SCI IF 3.487)
11. Y Zheng, YJ Guo, YT Li, Y. Wu, L.H. Zhang, ZJ Yang*, A novel gemini-like cationic lipid for the efficient delivery of siRNA, NewJ Chem.,2014, 38, 4952-4962. (SCI IF 3.159)
12. Y Huang, Y. Ma, YJ Guo, L Zou, HW Jin, LJ Zhong, Y Wu, L.H. Zhang, ZJ Yang*, Exploring directional invasion of serum nuclease into siRNA duplex via asymmetrical terminal modifications, ChemMedChem, 2014, 9, 2111-2119.(SCI IF 3.046)
13. Y Huang, Z Chen, Z Wang, YT Li, Y. Chen, YS Wang, ZJ Yang*, LH Zhang, Loss of silencing activity caused by 5’-terminal modification with D-/L-isonucleotide (isoNA) or locked nucleic acid (LNA) could not be restored by 5’-terminal phosphorylation, Sci. China-Chem., 2014, 57(2), 329-334.(SCI IF 1.516)
14. RM Wu, N Qi, YW Jia, Z Guan, LR Zhang, LH Zhang, ZJ Yang*, A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogues, Chin. Chem. Lett., 2014, 25, 1583-1585. (SCI IF 1.178)
15. L Zou, Y Huang, XF Wang, Y Ma, Y Liu, Z Guan*, LH Zhang, ZJ Yang*, Serum stability enhancement of siRNA caused by peptide conjugation at 3'-terminus of sense strand, J. Chin. Pharm. Sci., 2014, 23 (4), 211-214.
16. Y Huang, Z Chen, Y Chen, H Zhang, YC Zhang, YL Zhao, ZJ Yang*, LH Zhang*. The effects of conformational alteration induced by D-/L-isonucleoside incorporation in siRNA on their stability in serum and silencing activity, Bioconjugate Chem., 2013, 24, 951-959.(SCI IF 4.513)
17. YY Jiao,XQ Wang, WL Lu, ZJ Yang*, Q. Zhang*, A novel approach to improve the pharmacokinetic properties of 8-chloro-adenosine by the dual combination of lipophilic derivatisation and liposome formulation,Eur. J. Pharm. Sci., 2013, 48, 249-258.(SCI IF 3.350)
18. DL Pan, C Tang, XM Fan, YT Li, XT Yang, HW Jin, Z Guan, ZJ Yang*, LH Zhang, Thymidine based amphiphiles and their bonding to DNA, New J. Chem., 2013, 37, 1122-1127.(SCI IF 3.487)
19. CC Zhao*, XZ Wang, J Cao, P Peng, JX Zhang, YF Zhang, Y Yang, ZJ Yang*, BODIPY-based sulfoxide: synthesis, photophysical characterization and response to benzenethiols, Dyes Pigment., 2013, 96(2), 328-332.(SCI IF 3.966)
20. XF Wang, Ye Huang, Y Liu, Y Chen, HW Jin, Y Zheng, Q Du, ZJ Yang*, LH Zhang, Synthesis and biological evaluation of peptide-siRNA conjugates with phosphodiester unit as linker, Sci. China Chem., 2013, 56(11), 1542-1549.(SCI IF 1.516)
21. LJ Xie, XT Yang, DL Pan, YL Cao, M Cao, GC Lin, Z. Guan*, Y Guo, LH Zhang and ZJ Yang*, Synthesis and anti-HIV activity of 2’,3’-dideoxyguanosine and 2’,3’-didehydro-2’,3’-dideoxy-guanosine analogs, Chin. J. Chem., 2013, 31, 1207-1218.(SCI IF 1.578)
22. XF Wang, XT Yang, Y Chen, Y Liu, L Zou, ZJ Yang*, LH Zhang, Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit, Chin. Chem. Lett., 2013, 24, 873-876.
23. LX Na, M Wang, XL Sun, KF Li, L Xing, Z Chen, ZJ Yang*, Atropisomerism of diastereomer diribonucleoside phosphotriester, Chin. Chem. Lett., 2013, 24,13-16.(SCI IF 1.178)
24. YT Li, Y. Zheng, DL Pan, B Xu, Y Wu*, Z.J. Yang, LH Zhang, Development of a high-content screening method to evaluate the cellular population-based biological actvity of new siRNA delivering reagent,J. Chin. Pharm. Sci., 2013, 22(6), 467-474.
25. XX Li, JJ Hou, C Wang, XJ Liu, HY He, P Xu, ZJ Yang, ZL Chen*, Y Wu*, LH Zhang, Synthesis and biological evaluation of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy, Molecules, 2013, 18(11), 13957-13978.(SCI IF 2.416)
26. M. Wang, L. Xing, S.F. Lu, Z. Guan*, Z.J. Yang, L.H. Zhang, Synthesis and the anti-HIV activity of novel dinucleotides containing L-isonucleosides, J. Chin. Pharm. Sci., 2013,22(4), 314-318.
27. Y Yang, ZJ Yang, CR Cheng, Qing, FL*, Synthesis and antitumor activity evaluation of gamma-monofluorinated and gamma,gamma-difluorinated goniothalamin analogues, Chin. J. Chem., 2013, 31(6), 805-812. (SCIIF 1.578)
28. W Peng, JX Chen, YC Qin, ZJ Yang, YY Zhu*, Long double-stranded multiplex siRNAs for dual genes silencing, Nucleic Acid Therapeutics, 2013, 23(4), 281-288.(SCI IF 2.929)
29. J Zhang, Y Chen, Y Huang, HW Jin, RP Qiao, L Xing, LR Zhang, ZJ Yang*, LH Zhang*, Synthesis and properties of a novel L-isonucleosides modified oligonucleotides and siRNAs, Org. Biomol. Chem., 2012, 10 (37), 7566 - 7577. (SCI IF 3.487)
30. Y Liu, XF Wang, Y Chen, LH Zhang, ZJ Yang*, A solid-phase method for peptide-siRNA conjugates based on Click Chemistry, MedChemComm, 2012, 3 (4), 506-511. (Sci IF 2.800)
31. Y Huang, XF Wang, ZJ Yang*, LH Zhang Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation(Review), J. Chinese Pharm. Sci., 2012, 21(4), 499–508.
32. 那路新, 杨振军*, 环二鸟苷酸(c-di-GMP) 在微生物体内的作用及其类似物的研究(Review), 药学学报(Acta Pharmaceutica Sinica), 2012, 47(3), 307-312.
33. Y Chen, XF Wang, Y Huang, LH Zhang, ZJ Yang*, Chemically modified siRNAs and their conjugates (Review), J. Chin. Pharm. Sci., 2012, 21(1), 5-20.
34. F Wang, Y Chen, Y Huang, HW Jin, LR Zhang, ZJ Yang*, LH Zhang,Synthesis, physicochemical, biological properties of oligonucleotides incorporated with amino-isonucleosides, Sci. China-Chem., 2012, 55 (1), 70-79. (Sci IF 1.199)
35. N. Qi, K. Jung, M. Wang, L. X. Na, Z. J. Yang*, L. R. Zhang, A. H. Guse, L. H. Zhang*, A novel membrane permeant cADPR antagonist modified in the pyrophosphate bridge, Chem. Commun.,2011, 47, 9462–9464. (SCI IF 6.718)
36. JFLu,LJXieMCao,ZGuan*,YGuo,ZJYang*,LiHeZhang, The prodrugs of Lguanosine analogs: design, synthesis andantiHIVactivity, J. Chin. Pharm. Sci., 2011, 20,335–341.
37. M Dong,YQ Si,SY Sun,XP Pu,ZJ Yang,LR. Zhang, LH. Zhang*,FP Leung,CM Ching,Lam,AK Yee Kwong,JB Yue,YY Zhou, IA Kriksunov,Q Haoand HC Lee*, Design, synthesis and biological characterization of novel inhibitors of CD38,Org. Biomol. Chem., 2011, 9, 3246–3257. (SCI IF 3.451)
38. L Pei, LJ Xie, Q Lin, XM Ling*, Z Guan, ZJ Yang*, Studies on the adenosine deaminase-catalyzed conversion of adenosine and nucleoside prodrugs by different capillary electrophoresis modes, Anal. Biochem., 2011, 414, 131–137. (SCI IF 2.996)
39. ZY Hu, XY Liu, XM Liu, ZJ Yang*, YY Wang*. Calf spleen extract alleviates cyclophosphamide-induced leucopenia in mice and inhibits the glycolysis of HL60 cells.J Chin Pharm Sci.2011, 20, 181-187.
40. ZJ Yang*, XF Wang, Y Liu, Y Chen, FL Nie, LH Zhang, Synthesis and biological properties of peptide-siRNA conjugates, 161-166, Peptides Chemistry, Biology and Pharmaceutical Sciences, Edited by Rui Wang, Kai-Rong Wang, Proceeding of the 11thChinese International Peptide Symposium, July 5-8, 2010, Lanzhou, China, 2011, 7.
41. Y Zhou, PL Yu, HW Jin, ZJ Yang, JB Yue, LR Zhang*, LH Zhang, Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications. Molecules, 2012, 17, 4343-4356.(SCI IF 2.416)
42. S Wang, HX Ren, J Xu, YJ Yu, SP Han, H Qiao, SL Cheng, C Xu, SC An, BM Ju, CY Yu, CY Wang, T Wang, ZJ Yang,EW Taylor, LJ Zhao*, Diminished serum repetin levels in patients with schizophrenia and bipolar disorder, Scientific Reports, 2015, 5,7977-85.(SCIIF 5.578)
43. Y Zhou, PL Yu, Jin, ZJ Yang, JB Yue, LR Zhang*, LH Zhang, Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications, Molecules, 2012, 17(4), 4343-4356.(SCI IF 2.416)
44. Z Chen, AKY Kwong, ZJ Yang, LR Zhang*, HC Lee, LH Zhang, Synthesis and biological evaluation of nicotinamide adenine dinucleotides analogues as inhibitors of CD38, Chem. J. Chin. Univ.-Chin.,2012, 33(6), 1226-1232.
45. Y Wang, L Wu, P Wang, C Lv, ZJ Yang, XJ Tang*,Manipulation of gene expression in zebrafish using caged circular morpholino oligomers, Nucleic Acids Res., 2012, 40, 11155-11162.(Sci IF 9.112)
46. 陈哲, Anna Ka Yee Kwong, 杨振军，张亮仁*，Hon Cheung Lee, 张礼和，烟酰胺腺嘌呤二核苷酸(NAD)类CD38抑制剂的合成及活性评价, 高等学校化学学报, 2012, 33, 1226-1232.
47. 马宇衡，徐波，崔景荣，杨振军，张亮仁，张礼和, 三肽四氮唑类20S蛋白酶体抑制剂的设计、合成与活性研究, 药学学报, 2012, 47, 472-478.
48. Y. Zhou, PL Yu, ZJ Yang, LR Zhang*, LH Zhang, Design and synthesis of cADPR analogues with simplified ribose and nucleobase. J. Chin. Pharm. Sci., 2012, 21, 287-291.
49. 陈哲, 杨振军, 张亮仁*, 张礼和, 氟代烟酰胺核苷磷酸酯的一釜合成, 中国药物化学杂志, 2012, 22, 104-112.
50. YH Ma, B Xu,Y Fang, ZJ Yang,JR Cui,LR Zhang, LH Zhang, Synthesis and SAR study of novel peptide aldehydes as inhibitors of 20S proteasome, Molecules,2011, 16(9), 7551-7564.(SCI IF 2.416)
51. Z Chen,AKY Kwong, ZJ Yang, LR Zhang,HC Lee,LH Zhang,Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 nadase, Heterocycles,2011, 83(12), 2837-2845.(SCI IF 1.079)
52. YH Ma,LL Qu,ZM Liu, LR Zhang,ZJ Yang,LH Zhang,Synthesis of salinosporamide A and its analogs as 20S proteasome inhibitors and SAR summarization, Curr.Topics Med..Chem.,2011, 11(23), 2906-922.(SCI IF 3.402)
53. WJ Li, YL Ma, Z Guan, XM Ling*, ZJ Yang, Qualitative and quantitative determination of oligonucleotides by non-gel capillary electrophoresis, Chromatographia, 2011, 73(5-6), 579-582.(SCI IF 1.414)
科研项目