2010-10-22学术报告（药学院二楼会议室）

学术报告

报告人：肖相树  博士

报告题目：Drugging the Undruggable: Small Molecule Inhibitors of CREB-CBP as Anticancer Agent

报告时间：2010年10月22日上午10点

包地点：药学楼二楼会议室

肖相树博士介绍：

Assistant Professor

Department of Physiology and PharmacologyOregon Health & Science University

Portland, OR 97239USA

教育背景：

Aug. 2001-Jun. 2005     Ph.D., Medicinal Chemistry, Purdue University, West Lafayette, Indiana

Advisor: Prof. Mark Cushman

Sep. 1998-Jun. 200       M.Sc., Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Advisor: Prof. Donglu Bai

Sep. 1994-Jun. 1998      B.Sc., Medicinal Chemistry, Beijing Medical University, Beijing, China

Advisor: Prof. Lihe Zhang

工作经历：

Aug. 2007-present  Assistant Professor      Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR

Jul. 2005-Jul. 2007Post-doctoral Fellow, Chemical Biology, University of Texas Southwestern Medical Center, Dallas, Texas 

代表文章：

1.       Xiao, X.;*Li, B. X.; Mitton, B.; Ikeda, A.; Sakamoto, K. M. “Targeting CREB for Cancer Therapy: Friend or Foe” Current Cancer Drug Targets, 2010, 10, 384-391.

2.       Li, B. X.; Xiao, X.* “Discovery of a Small Molecule Inhibitor of KIX-KID Interaction” ChemBioChem 2009, 10, 2721-2724.

3.       Xiao, X.; Yu, P.; Lim, H.; Sikder, D.; Kodadek, T.* “Design and Synthesis of a Cell Permeable Synthetic Transcription Factor Mimic” J. Comb. Chem., 2007, 9, 592-600.

4.       Xiao, X.; Yu, P.; Lim, H.; Sikder, D.; Kodadek, T.* “A Cell-Permeable Synthetic Transcription Factor Mimic” Angew. Chem. Int. Ed., 2007, 46, 2865-2868.

5.       Xiao, X.; Morrell, A.; Fanwick, P.; Cushman, M.* “On the Mechanism of Conversion of 4-Carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to Indeno[1,2-c]isoquinolines by Thionyl Chloride” Tetrahedron, 2006, 62, 9705-9712.

6.       Xiao, X.; Antony, S.; Pommier, Y.; Cushman, M.* “Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine” J. Med. Chem. 2006, 49, 1408-1412.

7.       Xiao, X.; Cushman, M.* “Effect of E-ring Modifications in Camptothecin on Topoisomerase I Inhibition: A Quantum Mechanics Treatment” J. Org. Chem. 2005, 70, 9584-9587.

8.       Xiao, X.; Cushman, M.* “A Facile Method to Transform trans-4-Carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to Indeno[1,2-c]isoquinolines” J. Org. Chem. 2005, 70, 6496-6498.

9.   Xiao, X.; Cushman, M.* “An ab initio Quantum Mechanics Calculation that Correlates with Ligand Orientation and DNA Cleavage Site Selectivity in Camptothecin-DNA-Topoisomerase I Ternary Cleavage Complexes” J. Am. Chem. Soc. 2005, 127, 9960-9961.

李润涛 课题组